ANTIBACTERIAL PROPERTIES OF CARICAPAPAYA (PAWPAW) LEAF EXTRACT ON SOME PATHOGENIC BACTERIA OF PUBLIC HEALTH IMPORTANCE

Abstract

This study investigated the antibacterial activity of Carica papaya leaf extracts against pathogenic bacteria, aiming to explore the potential of natural remedies in combating bacterial infections. The rising global concern of antibiotic resistance necessitates the exploration of alternative therapeutic options. Carica papaya leaves, known for their traditional medicinal use contain bioactive compounds with potential antimicrobial properties. The study employed in vitro assays to assess the antibacterial effects of Carica papaya leaf extracts against a range of pathogenic bacteria, both Gram-positive and Gram-negative. The assays revealed substantial
zones of inhibition, indicating the ability of the extracts to impede bacterial growth. Minimum inhibitory concentration (MIC) values further underscored the potency of the extracts. These findings align with earlier studies identifying alkaloids, flavonoids, and phenolic compounds in Carica papaya leaves with antibacterial attributes. However, challenges such as variability in bioactive compound composition and lack of in vivo data warrant further research. Mechanistic studies, clinical trials, formulation development, and safety assessments are recommended to advance the understanding and potential application of Carica papaya leaf extracts as an alternative antibacterial treatment. Integrating traditional knowledge with modern scientific methodologies holds the promise of addressing the pressing issue of antibiotic resistance.